OXYUREA 100mg capsules contain hydroxyurea, a prescription antimetabolite medication designed to slow abnormal cell growth. This therapeutic agent effectively manages chronic myeloid leukemia, polycythemia vera, ovarian cancer, squamous cell cancer of the head and neck, and sickle cell anemia.
Uses
OXYUREA is prescribed under strict medical supervision for treating various cancers and blood disorders. It effectively manages chronic myeloid leukemia, reduces complications in polycythemia vera, treats certain skin cancers, controls ovarian cancer progression, and prevents painful crises in sickle cell anemia.
Benefits
- Specifically targets rapidly dividing cancer cells
- Reduces frequency of sickle cell pain crises
- Decreases need for blood transfusions
- Minimizes blood clot risks
- Offers convenient oral administration
- Prevents need for spleen removal
- Extends disease remission periods
- Serves as alternative when other treatments fail
How It Works
Hydroxyurea functions by interfering with DNA synthesis and repair in rapidly dividing cells. This mechanism helps control abnormal cell growth while allowing healthy cells to maintain normal function, making it effective for both cancer treatment and blood disorder management.
Dosage
| Medical Condition | Initial Dose | Maintenance Dose & Frequency |
|---|---|---|
| Chronic Myeloid Leukemia | 1000mg | 1000-2000mg daily |
| Sickle Cell Anemia | 500mg | 1000mg once daily |
| Polycythemia Vera | 500mg | 500-1000mg daily, adjusted based on response |
| Ovarian Cancer | 1000mg | 1000-2000mg daily |
| Head and Neck Cancer | 1000mg | 1000-2000mg daily |
Duration of Action
OXYUREA typically shows initial effects within 2-3 weeks of consistent use. Maximum therapeutic benefits may take 3-6 months to achieve. Regular monitoring and dose adjustments may be necessary throughout treatment.
Side Effects
Common side effects of OXYUREA 100mg include decreased appetite, nausea, fatigue, and skin changes. More serious effects can involve bone marrow suppression leading to low blood counts. Regular blood monitoring is essential during treatment to manage potential complications.
Warning
Discontinue use and seek immediate medical attention if experiencing severe side effects such as unusual bleeding, persistent fever, skin ulcers, or difficulty breathing. OXYUREA should only be taken under close medical supervision.
Pregnancy and Breastfeeding
OXYUREA is contraindicated during pregnancy and breastfeeding due to potential serious risks to the developing fetus or infant. Effective contraception must be used during treatment and for at least 6 months after discontinuation.
Interactions
- May increase toxicity of other chemotherapy drugs
- Can interact with live vaccines
- Potential interaction with antiretroviral medications
- May enhance effects of radiation therapy
Precautions
Regular blood tests are mandatory during treatment. Maintain adequate hydration and follow strict infection prevention measures. Avoid activities that may cause injury due to increased bleeding risk. Report any new symptoms promptly.
Important Information
OXYUREA 100mg requires consistent monitoring through blood tests and medical examinations. Never adjust dosage without medical consultation. Take medication with plenty of water. Store capsules in a cool, dry place away from light. Report any new or worsening symptoms promptly to your healthcare provider.
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